Hebbian analysis of the transformation of medial entorhinal grid - cell inputs 5 to hippocampal place fields
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4 Hebbian analysis of the transformation of medial entorhinal grid-cell inputs 5 to hippocampal place fields 6 7 8 9 10 Francesco Savelli and James J. Knierim 11 12 Zanvyl Krieger Mind/Brain Institute 13 Solomon H. Snyder Department of Neuroscience 14 Johns Hopkins University 15 Baltimore, MD 16 17 Department of Neurobiology and Anatomy 18 University of Texas Medical School at Houston 19 Houston, TX 20 21 22 23 24 25 26 27 Running head: Grid cell to place cell transformation 28 29 30 Contact information (corresponding author): 31 32 Francesco Savelli ([email protected]) 33 Zanvyl Krieger Mind/Brain Institute 34 Johns Hopkins University 35 Baltimore, MD 36 338 Krieger Hall 37 3400 North Charles Street 38 Baltimore, MD 21218 39 40 Phone: 410-516-5057 41 Fax: 410-516-8648 42 43 44 Articles in PresS. J Neurophysiol (March 31, 2010). doi:10.1152/jn.00932.2009
منابع مشابه
Hebbian analysis of the transformation of medial entorhinal grid-cell inputs to hippocampal place fields.
The discovery of grid cells in the medial entorhinal cortex (MEC) permits the characterization of hippocampal computation in much greater detail than previously possible. The present study addresses how an integrate-and-fire unit driven by grid-cell spike trains may transform the multipeaked, spatial firing pattern of grid cells into the single-peaked activity that is typical of hippocampal pla...
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Hippocampal place fields, the local regions of activity recorded from place cells in exploring rodents, can undergo large changes in relative location during remapping. This process would appear to require some form of modulated global input. Grid-cell responses recorded from layer II of medial entorhinal cortex in rats have been observed to realign concurrently with hippocampal remapping, maki...
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The rodent hippocampus and entorhinal cortex contain spatially modulated cells that serve as the basis for spatial coding. Both medial entorhinal grid cells and hippocampal place cells have been shown to encode spatial information across multiple spatial scales that increase along the dorsoventral axis of these structures. Place cells near the dorsal pole possess small, stable, and spatially se...
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The large capacity of episodic memory is thought to be supported by the emergence of distinct hippocampal cell assemblies for unrelated memories, such that interference is minimized. In large-scale population recordings, the orthogonal nature of hippocampal representations across environments is evident in the complete reorganization of the firing locations of hippocampal place cells. Entorhina...
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تاریخ انتشار 2010